Choroid Plexus Area and Permeability in Dementia with Lewy Bodies

Motivation: The choroid plexus has been demonstrated to play a significant role in the pathophysiology of dementia with Lewy bodies (DLB), however the imaging characteristics are not yet explored. Goal(s): Our goal was to assess choroid plexus area and permeability based on MRI in DLB patients. Approach: DLB patients were imaged to acquire choroid plexus area and permeability and compared with patients with Alzheimer’s disease and healthy controls. Results: DLB patients exhibited larger area and lower fractional plasma volume in choroid plexus than healthy controls. Additionally, they were found to be significantly associated with the mini-mental state examination score. Impact: The larger choroid plexus area and lower fractional plasma volume detected by T1-weighted MRI and DCE-MRI in dementia with Lewy bodies provide a non-invasive and quantitative metric for advancing the diagnosis and treatment of dementia with Lewy bodies.