Linear Regression Modeling of BOLD Response to task activation reflects neurovascular uncoupling in MS

Motivation: To understand the different BOLD activation pattern in multiple sclerosis patientsGoal(s): To Investigate the neuro-vascular uncoupling of MS patients to be compared with healthy controlsApproach: During the visual task and hypercapnia challenge, BOLD and CBF are measured simultaneously with EEG in patients of MS (n=11) and health controls (n=15). Results: We find that, for healthy controls, only models that included neuronal activity, i.e. EEG power change during task performance, were significantly predictive of BOLD responseImpact: We investigate BOLD activation of MS patients and compare with controls using EEG simultaneously during a visual task and hypercapnia challenge. We find that the BOLD response in MS does not directly depend on the degree of underlying neuronal activity.