Cardiovascular MRI study of the relationship between right ventricular function and biventricular shape in repaired tetralogy of Fallot

Motivation: In patients with repaired tetralogy of Fallot prolonged exposure to the right ventricular (RV) pressure and/or volume overload can affect the function of both RV and left ventricle (LV). Goal(s): We aimed to investigate the link between RV function and RV and LV shape variation. Approach: We combined biomechanical modeling (i.e., provides RV contractility) with statistical shape modeling to quantify function and shape interaction. Results: Higher values of RV contractility were associated with a compressed LV cavity with associated septal flattening. No meaningful relationship was identified between RV function and RV endocardial shape. Impact: The link between anatomy and function can be studied with unprecedented detail in rTOF by combining biomechanical and statistical modeling frameworks from MRI. Such an approach facilitates the discovery of new disease mechanisms.