Investigating Quantitative Perfusion Characteristics of Prostate Cancer for African American and White Men

Motivation: Race and ethnicity strongly impact the risk of prostate cancer, and understanding the impact of biological heterogeneity in patients from different racial/ethnic backgrounds is crucial for reducing the observed gaps in clinical outcomes. Goal(s): To investigate potential differences in quantitative perfusion characteristics of prostate cancer between African American and White men. Approach: After matching commonly known clinical risk factors, the quantitative DCE-MRI analysis was performed to assess differences in perfusion parameters of the pathology- and MRI-based lesions African American and White men. Results: Notable differences between the two cohorts were observed in the Ktrans of tumors with csPCa. Impact: Considering race-specific perfusion characteristics can help in understanding biological factors of health disparity in prostate cancer.