Perturbation of intrinsic oscillatory modes by focal ischemic stroke in rats

Motivation: The biophysical mechanisms underlying changes in functional connectivity upon stroke remain unclear. Goal(s): The present study aims at investigating how disrupting a specific and well-localized cortical area modulates spontaneous long-range functional connectivity. Approach: A novel approach based on intrinsic oscillatory modes exhibiting stationary wave pattern features was used to provide insight into the organizing principles underpinning spontaneous long-range FC. Results: The presented intrinsic mode framework revealed global reorganization following local disruption with enhancement of corticostriatal activity in stroke. Impact: Our findings provide an important insight augur well for better understanding of neural network reorganization.