Trajectories of abdominal subcutaneous and visceral adipose tissue accumulation and cardiometabolic health in children: The GUSTO study
Motivation: Unravel the links between childhood abdominal fat distribution patterns and subsequent cardiometabolic risks aiming to provide effective strategies for preventing childhood obesity. Goal(s): To investigate the presence of distinct abdominal fat accumulation patterns during infancy and childhood in a multi-ethnic cohort, and their associations with cardiometabolic risk. Approach: Latent class growth mixture modeling was used to identify three trajectories (stable, slow acceleration, rapid acceleration) for deep subcutaneous (DSAT), superficial subcutaneous (SSAT), and visceral adipose tissues (VAT). Results: Compared to Chinese children, Indian children had higher odds of being in the rapid acceleration trajectory. All accelerated trajectories were associated with inflammatory marker, hsCRP. Impact: This research has the potential to impact public health by providing evidence-based insights into the relationships between abdominal fat distribution patterns and cardiometabolic health. Our findings may aid development of targeted interventions and strategies to mitigate long-term adverse cardiometabolic consequences.
Authors
- Yap Seng Chong (ORCID: https://orcid.org/0000-0002-7232-8473)
- Johan G. Eriksson (ORCID: https://orcid.org/0000-0002-2516-2060)
- S. Sendhil Velan (ORCID: https://orcid.org/0000-0002-4096-0722)
- Yeshe Kway (ORCID: https://orcid.org/0000-0001-6726-2425)
- Keith M. Godfrey (ORCID: https://orcid.org/0000-0002-4643-0618)
- Varsha Gupta (ORCID: https://orcid.org/0000-0003-1315-1062)
- Dennis Wang (ORCID: https://orcid.org/0000-0003-0068-1005)
- Peter D. Gluckman (ORCID: https://orcid.org/0000-0002-5711-1655)
- Kok Hian Tan (ORCID: https://orcid.org/0000-0003-1945-0266)
- Navin Michael (ORCID: https://orcid.org/0000-0002-6170-2108)
- Kashthuri Thirumurugan
- Yung Seng Lee (ORCID: https://orcid.org/0000-0002-1253-0557)
- Fabian Yap (ORCID: https://orcid.org/0000-0003-1083-7958)
- Mya Thway Tint (ORCID: https://orcid.org/0000-0002-9548-7186)
- Suresh Anand Sadananthan (ORCID: https://orcid.org/0000-0001-5938-1694)
- Marielle V. Fortier (ORCID: https://orcid.org/0000-0002-3294-1054)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0289
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 0.00