KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency
While KF4 might be an alternative to AAT replacement, combined KF4 and AAT replacement does not confer additional benefit.
Authors
- Basilia Zingarelli (ORCID: https://orcid.org/0000-0003-0152-700X)
- Emily Goodman (ORCID: https://orcid.org/0000-0002-3714-4310)
- Brian Michael Varisco (ORCID: https://orcid.org/0000-0003-0180-2577)
- Noah J. Smith (ORCID: https://orcid.org/0009-0000-2711-6255)
- Brandon Brooks-Patton
- Ansley N. Varisco
- Qiang Fan
- Andrew J. Devine
- Jenna Dunham
- Rashika Joshi
Institutions
- University of Arkansas at Little Rock (US)
- Cincinnati Children's Hospital Medical Center (US)
- Arkansas Children's Hospital (US)
- Northern Kentucky University (US)
- Ohio University (US)
- University of Arkansas for Medical Sciences (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation
- Published
- 2024-11-26
- DOI
- https://doi.org/10.15326/jcopdf.2024.0535
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences