Targeting Motor and Cognitive Impairments: Comparative Insights into STN-DBS and NAc-DBS Efficacy in Parkinson's Disease Model with Metabolism

Motivation: Addressing subthalamic nucleus deep brain stimulation (STN-DBS) limitations in Parkinson's Disease (PD), such as metabolic disorder and cognitive dysfunction. We explored nucleus accumbens deep brain stimulation (NAc-DBS) as an alternative, aiming to enhance motor, cognitive, and metabolic functions comprehensively. Goal(s): Investigate NAc-DBS effectiveness, bridging STN-DBS gaps, enhancing motor skills, and improving cognitive and metabolic functions in PD. Approach: Utilized behavioral tests, brain magnetic resonance imaging analysis, and bioenergetic analysis to evaluate NAc-DBS and STN-DBS impact on the MitoPark PD mouse model. Results: NAc-DBS significantly enhanced cognitive, motor functions, and energy metabolism, offering a promising therapeutic solution for PD patients. Impact: Our findings transform Parkinson's treatment, sheding a light to patients. The dual benefits of NAc-DBS inspire new inquiries, reshaping therapies with metabolic modulation. Improved outcomes redefine standards, offering hope for enhanced quality of life.