Connectome 2.0: Performance evaluation and initial in vivo human brain diffusion MRI results
Motivation: Current human MR scanners cannot resolve the full range of length scales needed to study the brain's microscopic and mesoscopic structure. Goal(s): To construct and validate the next-generation human connectomics and microstructure MRI scanner known as Connectome 2.0. Approach: The 3T Connectome 2.0 scanner incorporates a peripheral nerve stimulation-optimized asymmetric head gradient driven by dual gradient power amplifiers. Custom-built high-sensitivity 72-channel (in vivo imaging) and 64-channel (ex vivo imaging) receive coils were integrated. Results: The Connectome 2.0 scanner achieves Gmax=500 mT/m and SRmax=600 T/m/s, demonstrates 2x improved SNR for diffusion MRI over Connectome 1.0, and enables high-resolution tractography. Impact: The Connectome 2.0 scanner will allow the exploration of new microstructure properties and connectional anatomy in the living human brain with unprecedented spatial and diffusion resolution.
Authors
- Bruce Robert Rosen (ORCID: https://orcid.org/0000-0002-8576-0839)
- Lawrence L. Wald (ORCID: https://orcid.org/0000-0001-8278-6307)
- Mirsad Mahmutović (ORCID: https://orcid.org/0000-0001-9178-4194)
- Joseph B. Fischer
- Thomas Witzel (ORCID: https://orcid.org/0000-0002-5806-4897)
- Peter J. Basser (ORCID: https://orcid.org/0000-0003-4795-6088)
- Hong‐Hsi Lee (ORCID: https://orcid.org/0000-0002-3663-6559)
- Andreas Potthast
- Daniel Park (ORCID: https://orcid.org/0000-0002-7263-9327)
- Mathias Davids (ORCID: https://orcid.org/0000-0003-0217-9123)
- Wei‐Ching Lo (ORCID: https://orcid.org/0000-0002-1893-0500)
- Rebecca Ramb
- Bryan Clifford (ORCID: https://orcid.org/0000-0002-1966-0581)
- Elmar Rummert
- Chiara Maffei (ORCID: https://orcid.org/0000-0002-3837-0635)
- Boris Keil (ORCID: https://orcid.org/0000-0003-0805-8330)
- Berkin Bilgic̦ (ORCID: https://orcid.org/0000-0002-9080-7865)
- Stefan Stocker
- Gabriel Ramos‐Llordén (ORCID: https://orcid.org/0000-0003-4020-705X)
- John E. Kirsch (ORCID: https://orcid.org/0000-0002-0389-9475)
- Alina Scholz (ORCID: https://orcid.org/0000-0002-3324-6889)
- Anastasia Yendiki (ORCID: https://orcid.org/0000-0003-1386-3828)
- Thomas Benner
- Susie Y. Huang (ORCID: https://orcid.org/0000-0003-2950-7254)
- Hansol Lee (ORCID: https://orcid.org/0000-0002-6270-1203)
- Yixin Ma (ORCID: https://orcid.org/0000-0003-0894-5909)
- Andreas Krug
- Peter Dietz (ORCID: https://orcid.org/0009-0002-1803-0892)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0904
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00