MRI changes of lumbar vertebrae and paraspinal muscles predict vertebral fractures in patients with type 2 diabetes

Motivation: Patients with T2DM are at an increased risk of vertebral fractures, but the specific risk factors remain unclear. Goal(s): Investigate the correlation between changes in lumbar vertebrae and paravertebral muscles observed through MRI and the occurrence and severity of vertebral fractures in T2DM patients. Approach: Retrospectively collect general information and lumbar spine MRI images of patients diagnosed with T2DM. Develop a diagnostic model based on MRI vertebral body and paravertebral muscle parameters and evaluate the model's diagnostic performance. Results: Higher VBQ scores, decreased relative CSA of paravertebral muscles, and increased fat infiltration of the paravertebral muscles indicate an elevated risk of fractures. Impact: The findings of this study could potentially have a significant impact on the management and prevention of vertebral fractures in T2DM patients. By identifying specific MRI-based risk factors, clinicians can improve fracture risk assessment and implement targeted interventions.