Paeoniflorin's Cardioprotective Role in High-Altitude MI: A CMR Study

Motivation: To investigate the cardioprotective effects of paeoniflorin on myocardial infarction-induced ventricular remodeling in high-altitude hypobaric hypoxia environments. Goal(s): To evaluate the potential protective role of paeoniflorin in a rat model of myocardial infarction-induced ventricular remodeling under high-altitude hypobaric hypoxia using cardiovascular magnetic resonance strain analysis. Approach: Rats were allocated to plain sham operation control, high-altitude sham operation control, high-altitude myocardial infarction operation, and paeoniflorin treatment groups. CMR assessed cardiac function. Results: Paeoniflorin treatment groups demonstrated enhanced left ventricular function and regional strains compared to the myocardial infarction group. Histological analyses also showed reduced myocardial injury and fibrosis with paeoniflorin treatment. Impact: The study's outcomes have implications for managing patients at risk of MI, especially those in high-altitude environments or exposed to hypobaric hypoxia.