Validation of Resting State Functional Connectivity of S2 in Squirrel Monkey Brain: Comparisons with Optogenetic and Tactile fMRI

Motivation: To validate the derivation of functional networks from resting state and confirm the contribution of specific neuron types to BOLD responses. Goal(s): Our aim is to compare resting state BOLD-derived functional networks with those from neuron-type selective optogenetic and natural tactile stimulationin the non-human primate brain. Approach: We compared the BOLD signals in the brains of squirrel monkeys under three conditions: in response to blue light optogenetic stimulation, vibrotactile stimulation of fingers, and in a resting state. Results: It shows the neural specificity of the optogenetic fMRI approach and its potential to enhance the understanding of brain circuits and connectivity within S2. Impact: This study's validation of functional networks from resting-state BOLD acquisitions and the confirmation of optogenetic fMRI's neural selectivity helps with the understanding brain function. These results encourage further investigations for deeper insights into neurological conditions.