Tailored Synthetic and Non-Synthetic (SNS) Optimization for pediatric neuroimaging

Motivation: Quantitative MR (qMR) relaxometry allows monitoring of pediatric neuropathology. However, acquiring qualitative and qMR imaging is time-consuming and challenging, especially in pediatric patients. Goal(s): To design a pulse sequence allowing both quantitative and non-synthetic weighted imaging, addressing the need for acceleration. Approach: MR Fingerprinting (MRF) is the gold standard for simultaneous qMR mapping but does not provide non-synthetic images. We compare MRF versions to sequences designed using the 1-Look-Ahead approach to optimize gray (GM) to white matter (WM) contrast, including periods of stable signal for non-synthetic imaging. Results: A promising signal control enabling quantitative mapping and good-quality weighted in vivo images. Impact: Demonstration of the feasibility of controlled contrast and signal stability for quantitative and qualitative Magnetic Resonance Fingerprinting using one-look ahead (1LA) flip angle design for accelerated scanning in the pediatric brain, increasing quality in T2-weighted images.