Putaminal spontaneous activity characterizes and predicts wearing-off in Parkinson’s disease

Motivation: Delayed detection of wearing off (WO) in Parkinson’s disease (PD) has a negative impact on quality of life. However, there is currently no method for WO prediction prior to treatment. Goal(s): To investigate whether resting-state functional MRI (rs-fMRI) could aid in WO prediction. Approach: Fractional amplitude of low-frequency fluctuation (fALFF) was quantified from rs-fMRI to determine whether spontaneous activity dysfunction could be a predisposing vulnerability related to WO. Results: Putaminal fALFF reduction was the independent predictor of WO development. Impact: Detection of putaminal fALFF reduction prior to treatment provides a quantitative metric to facilitate WO prediction and improve prognosis.