Sex-specific entorhinal cortex functional connectivity in cognitively normal older adults with amyloid-β pathology

Motivation: The sex-specific brain alteration in cognitively normal older adults with amyloid-β pathology was unclear. Goal(s): This study aimed to investigate the impact of sex and APOE genotype on the functional connectivity of the entorhinal cortex (ERC) in cognitively normal older adults with amyloid-β pathology. Approach: Using a large sample from the A4 study, the authors performed a comprehensive analysis comparing demographic information, cognitive performance, volumetric MRI data, and ERC functional connectivity. Results: Results revealed sex-specific differences in ERC connectivity, with males showing higher connectivity in the sensorimotor network and females exhibiting higher connectivity in the default mode, executive control, and reward networks. Impact: This study sheds light on the influence of sex and APOE genotype on the functional connectivity of the entorhinal cortex in cognitively normal older adults with amyloid-β pathology.