A clinical study of the hippocampus subregion in temporal lobe epilepsy patients with neurite directional dispersion and density imaging

Motivation: To explore the microstructural changes of hippocampal subregions in temporal lobe epilepsy(TLE) patients. Goal(s): The microstructure of hippocampal subregion in TLE patients was significantly changed, which would provide imaging basis for the diagnosis of MRI negative TLE patients. Approach: Using neurite orientation dispersion and density imaging (NODDI) combined with automatic segmentation technology to explore TLE changes in microstructure and volume of hippocampal subregion in patients. Results: This study demonstrated the ability of NODDI technique to detect the changes of hippocampal microstructure in TLE patients. NDI may be more able to highlight neuronal damage and fiber recombination in TLE patients. Impact: This study demonstrated the ability of NODDI technique to detect the changes of hippocampal microstructure in TLE patients. NDI may be more able to highlight neuronal damage and fiber recombination in TLE patients.