Brain atrophy in epilepsy, a function of etiology? A preliminary analysis
Motivation: The relationship of grey-matter atrophy in structural epilepsy across various etiologies remains poorly understood. Goal(s): To perform volumetric brain MRI analysis in the presence of structural epileptogenic brain lesions. Approach: 68 subjects with structural epilepsy were longitudinally imaged, grey-matter volume estimates were derived from SynthSeg segmentations and corrected for structural lesions with manual segmentation. Grey-matter volume change was assessed over five structural etiological groups and related to the Seizure Frequency Score. Results: Our data show significant correlation between grey-matter volume loss and the Seizure Frequency Score. We could find no clear trend across etiological groups in our primary analysis. Impact: Our analysis of grey-matter volume loss in structural epilepsy shows a correlation with the Seizure Frequency Score, supporting the concept of epilepsy-associated neurodegeneration and highlighting the importance of early diagnosis and treatment.
Authors
- Stefanie Chambers (ORCID: https://orcid.org/0009-0006-7463-6636)
- Ekaterina Pataraia (ORCID: https://orcid.org/0000-0002-1454-7600)
- Siegfried Trattnig (ORCID: https://orcid.org/0000-0003-1623-3303)
- Wolfgang Bogner (ORCID: https://orcid.org/0000-0002-0130-3463)
- Giuseppe Pontillo (ORCID: https://orcid.org/0000-0001-5425-1890)
- Lukas Haider (ORCID: https://orcid.org/0000-0002-1556-1770)
- Gregor J. Kasprian (ORCID: https://orcid.org/0000-0003-3858-3347)
- Matthias Tomschik (ORCID: https://orcid.org/0000-0002-6243-1178)
- Gilbert Hangel (ORCID: https://orcid.org/0000-0002-3986-3159)
- Christian Dorfer (ORCID: https://orcid.org/0000-0002-1843-7732)
- Johannes Koren (ORCID: https://orcid.org/0000-0002-5290-2837)
- Martha Feucht (ORCID: https://orcid.org/0000-0001-7691-8158)
- Philipp Lazen (ORCID: https://orcid.org/0000-0002-9952-3084)
- Katharina Moser
- Karl Rössler (ORCID: https://orcid.org/0000-0002-9249-8082)
- Florian Mayer (ORCID: https://orcid.org/0009-0007-1271-3314)
- Leo Hofer
- Christoph Baumgartner
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3086
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00