Combining ASL and MRE to Investigate the Impact of Perfusion on Renal Stiffness in Patients with CKD: A Preliminary Study

Motivation: The impact of renal perfusion on stiffness values is yet to be conclusively validated, which has hindered the diagnostic application of magnetic resonance elastography (MRE) in patients with chronic kidney disease (CKD). Goal(s): To explore the characteristics of renal perfusion and stiffness values in patients with CKD and their correlation. Approach: Renal MRE and arterial spin labeling (ASL) were used to measure renal stiffness and blood flow. The study employed t-test, receiver-operating characteristic curves, and Spearman correlation for data analysis. Results: The two techniques were effective in diagnosing CKD, simultaneously confirming the influence of perfusion factors on stiffness. Impact: This preliminary human study further supported the correlation between renal stiffness and perfusion, supporting the enhanced diagnostic efficacy of combining MRE and ASL for CKD, thus facilitating staging.