Investigating Gravitational Influence on Normal Lung Function Using PREFUL MRI on an Open Scanner

Motivation: Insights into the factors contributing to local ventilation and perfusion variation within the lungs are of crucial importance to improving patient care. Goal(s): To investigate the gravity dependent contributions to regional heterogeneity of normal lung function including ventilation and perfusion. Approach: With use of an open MRI system, participants were scanned in three positions to vary the direction of gravity experienced by the lungs. PREFUL analysis was employed to attain fractional ventilation, normalised perfusion, and associated Time-To-Peak markers. Results: Contributions from both gravity and physiological factors were observed in ventilation and perfusion distribution for each of the three positions. Impact: Enhanced understanding of the causes of functional variations in healthy lungs will allow physicians to make more informed decisions regarding patient care. Additionally, posture dependent lung function could serve as a marker for lung disease and support stratified treatment approaches.