MR Imaging of tumor vascular normalization: DCE and IVIM

Motivation: The prognosis for patients with advanced nasopharyngeal carcinoma is often poor. Although anti-angiogenic therapy can enhance the effectiveness of chemo-radiotherapy, drug resistance remains a challenging issue. Accurately monitoring the time window for vascular normalization is crucial. Goal(s): The objective of this study was to assess the value of DCE-MRI and IVIM-MRI in dynamically monitoring tumor vascular normalization. Approach: By applying different antiangiogenic therapies to preclinical models, this study evaluated the effectiveness of DCE and IVIM in monitoring tumor vascular normalization (TVN). Results: Preliminary results suggest that IVIM-MRI can potentially replace DCE-MRI in monitoring tumor vascular normalization. Impact: This study holds profound implications for the clinical application of anti-angiogenesis therapy. It provides valuable insights into the effectiveness of combination therapies and offers a deeper understanding of vascular normalization indicators. These findings could potentially improve treatment strategies.