Whole tumor amide proton transfer–weighted imaging histogram analysis to predict prostate cancer bone metastases: a preliminary study

Motivation: Accurate prediction of prostate cancer(PCa) bone metastases can be challenged by radiologists. The utility of APTw histogram methods for evaluating bone metastases involvement in PCa is still unclear. Goal(s): The purpose of this study was to evaluate APTw-derived whole-tumor histogram analysis parameters in predicting PCa bone metastases. Approach: Diagnostic performance was evaluated using ROC analysis and the AUC comparisons were conducted using the DeLong method. Results: Our preliminary research showed that whole-tumor histogram analysis of APTw images combined with clinical factors (tPSA, cT stage) showed good diagnosis efficiency in predicting PCa bone metastases while using 68Ga-PSMA PET/CT as the reference standard. Impact: Our preliminary research showed that whole-tumor histogram analysis of APTw images combined with clinical factors(tPSA, T stage) showed good diagnosis efficiency in predicting prostate cancer bone metastases while using 68Ga-PSMA PET/CT as the reference standard.