A repository-integrated framework for rapid clinical analysis of MR-derived hypoxia maps.

Motivation: Translation of quantitative biomarkers requires a reproducible and efficient analysis environment to underpin assessments of clinical utility. Goal(s): This study aimed to provide a 24-hour turnaround of clinically relevant MR-derived hypoxia maps for use in biopsy planning. Approach: The analysis framework was integrated into an XNAT imaging repository and applied to oxygen-enhanced and dynamic-contrast-enhanced images to quantify and map the extent of hypoxia within low-grade glioma. Results: A group of geo-dispersed researchers consistently delivered MR-derived hypoxia maps to the clinical study team for use alongside 18F-FDOPA PET in biopsy site definition prior to surgery. Impact: A framework of repository-integrated analysis enabled rapid turnaround of quantitative MR imaging biomarkers for clinical decision-making. Specifically, biopsy-planning using MR-derived hypoxia mapping of low-grade glioma was delivered with standardised, reproducible, auditable results in under 24 hours.