The altered brain activity in children with electrical status epilepticus during sleep: a preliminary study of resting-state fMRI

Motivation: The micro-structure alteration related to cognitive function impairment, and the mechanism of functional impairment in children withESES remains unclear. Goal(s): To investigate the brain activity in children with ESES, and the associations of the brain activity with cognitive performance. Approach: We observed the ReHo difference between the ESES group and the HCs. And the correlation analysis was used to explore the relationship between Reho values and cognitive test. Results: Compared with HCs, patients with ESES showed ReHo alteration in some brain regions. The correlation analysis revealed that increased ReHo in the right frontal gyrus was correlated with the decreased PRI. Impact: The distinct changes of spontaneous brain activity were measured by ReHo, which may be further suggest that the potential of RS-fMRI as a novel biomarker tool for identifying cognitive impairments on neural aspect.