Aberrant interstitial fluids may be associated with cognitive impairment in patients on chronic kidney disease

Motivation: Chronic kidney disease (CKD) leads to cognitive impairment; however, the pathophysiology remains unclear. Goal(s): This study aims to evaluate differences in interstitial fluids (ISF) between patients with CKD and healthy controls, and investigate correlation between ISF circulation with cognitive impairment. Approach: Spectral diffusion analysis was applied to measure the ISF fraction (fint). Results: A significant difference in fint was detected between the HD and HC groups in the right basa gangliaand biliteral centrum semiovale(CSO). In the CKD group, MoCA scores were negatively correlated with fint in the biliteral CSO. Impact: A novel approach to measure ISF exhibits the potential for detecting brain glymphatic dysfunction in patients with CKD, which provides unique insights into the pathological mechanisms of patients on CKD with cognitive impairment.