Cross-species fMRI reveals transcriptomically and behaviorally-dissociable autism neurosubtypes
Motivation: Resting-state fMRI (rsfMRI) studies have revealed atypical patterns of functional connectivity in autism. However, large heterogeneity in the manifestation of these alterations exists across samples and its etiopathological significance remains unclear. Goal(s): Here, we used cross-species rsfMRI to probe if distinct patterns of functional dysconnectivity observed across 20 genetic models can be identified in rsfMRI scans of individuals with idiopathic autism. Approach: We mapped whole brain functional connectivity in 20 genetic mouse models and in over 2000 individuals with and without autism. Results: Our work reveals two autism neurosubtypes characterized by divergent patterns of dysconnectivity, and dissociable transcriptomic and behavioral profiles. Impact: Connectivity alterations in idiopathic autism encode for etiologically-relevant information.
Authors
- Filomena Grazia Alvino
- Alberto Galbusera (ORCID: https://orcid.org/0000-0001-7213-0013)
- Michael Peter Milham (ORCID: https://orcid.org/0000-0003-3532-1210)
- Valerio Zerbi (ORCID: https://orcid.org/0000-0001-7984-9565)
- Marco Pagani (ORCID: https://orcid.org/0000-0002-6052-6931)
- Alessandro Gozzi (ORCID: https://orcid.org/0000-0002-5731-4137)
- Adriana Di Martino (ORCID: https://orcid.org/0000-0001-6927-290X)
- Michael Lombardo (ORCID: https://orcid.org/0000-0001-6780-8619)
- Ting Xu (ORCID: https://orcid.org/0000-0002-0065-3832)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0441
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00