Structural connectome shapes the maturation of cortical morphology from childhood to adolescence
Motivation: Cortical thinning is an important hallmark of the maturation of brain morphology during childhood and adolescence. However, the connectome-based wiring mechanism that underlies cortical maturation remains unclear. Goal(s): We aim to model how the maturational pattern of cortical morphology is shaped by white matter connectome architecture. Approach: We integrated neuroimaging, connectome, transcriptome analyses and computational modeling. Results: We found that the maturational patterns of cortical morphology are constrained by the white matter connectome and are particularly represented using a network-based diffusion model. Such constraints are predominantly located in frontoparietal nodes and are linked with the expression of genes associated with microstructural developmental processes. Impact: Our results highlight the importance of white matter network structure in shaping the coordinated maturation of regional cortical morphology, which demonstrates the feasibility of using a network model to reveal the maturational principle of cortical morphology from childhood to adolescence.
Authors
- Yanpei Wang (ORCID: https://orcid.org/0000-0001-8135-2881)
- Jia‐Hong Gao (ORCID: https://orcid.org/0000-0002-9311-0297)
- Mingrui Xia (ORCID: https://orcid.org/0000-0003-4615-9132)
- Shaozheng Qin (ORCID: https://orcid.org/0000-0002-1859-2150)
- Tianyuan Lei (ORCID: https://orcid.org/0000-0002-5921-5853)
- Weiwei Men (ORCID: https://orcid.org/0000-0002-3025-6379)
- Sha Tao (ORCID: https://orcid.org/0000-0002-0928-0681)
- Yong He (ORCID: https://orcid.org/0000-0002-7039-2850)
- Dingna Duan (ORCID: https://orcid.org/0000-0002-2678-9789)
- Zhilei Xu (ORCID: https://orcid.org/0000-0002-5155-6346)
- Tengda Zhao (ORCID: https://orcid.org/0000-0002-5160-8417)
- Xuhong Liao (ORCID: https://orcid.org/0009-0000-0170-2520)
- Qiongling Li (ORCID: https://orcid.org/0000-0001-6989-2981)
- Lianglong Sun (ORCID: https://orcid.org/0009-0007-0164-0893)
- Xinyuan Liang (ORCID: https://orcid.org/0009-0007-2141-405X)
- Shuping Tan
- Qi Dong (ORCID: https://orcid.org/0000-0002-7229-8040)
- Zilong Zeng
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0136
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00