Hyperoxic challenge combined with hyperpolarized 129-xenon dissolved-phase imaging in a porcine model of pulmonary embolism
Motivation: Pulmonary embolism (PE) is a leading cause of cardiovascular death. Timely diagnosis is crucial but challenging. Increasing inspired oxygen levels to 40% or above has proven an effective treatment in acute PE by altering pulmonary gas exchange. Goal(s): Our goal is to determine if hyperpolarized 129-xenon gas can diagnose PE. Approach: Hyperpolarized 129-xenon dissolved-phase imaging was evaluated by applying a hyperoxic challenge in a porcine PE model. Results: Whole lung assessment of dissolved-phase imaging indicates regional pulmonary gas exchange increases with higher inhaled oxygen levels. Nevertheless, hyperoxic challenge effects did not diagnose PE. Impact: The study shows great potential of a pulmonary gas exchange imaging with the application of dissolved-phase hyperpolarized 129Xe imaging throughout a hyperoxic challenge. Nevertheless, the method did not improve diagnosis of pulmonary embolism in our porcine animal model.
Authors
- Jim M. Wild (ORCID: https://orcid.org/0000-0002-7246-8660)
- Rolf F. Schulte (ORCID: https://orcid.org/0000-0002-1334-1264)
- Jacob B. Hansen (ORCID: https://orcid.org/0000-0001-5249-2586)
- Guilhem Collier (ORCID: https://orcid.org/0000-0002-1874-4775)
- Graham Norquay (ORCID: https://orcid.org/0000-0002-4108-9035)
- Asger Andersen (ORCID: https://orcid.org/0000-0002-9102-3130)
- Esben Søvsø Szocska Hansen (ORCID: https://orcid.org/0000-0001-5512-9870)
- Christoffer Laustsen (ORCID: https://orcid.org/0000-0002-0317-2911)
- Michael Væggemose (ORCID: https://orcid.org/0000-0001-7666-6819)
- Margit Kristensen (ORCID: https://orcid.org/0000-0002-9667-2789)
- Mohsen Redda (ORCID: https://orcid.org/0009-0007-8972-4820)
- Oliver Rodgers
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3198
- Primary Topic
- Atomic and Subatomic Physics Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00