Magnetic Resonance Elastography captures tumor invasiveness and therapy response in the invasive S24-glioma model
Motivation: In a neurooncological setting clinically established MRI-sequences have shortcomings with regards to tumor invasion and therapy-associated parenchyma changes. Goal(s): Our goal was to determine if MRE and the ADC could improve detection of tumor cell invasion and radiotherapy effects. Approach: 23 tumor-bearing mice and 9 sham injected mice underwent MRE- and MRI-scans for up to 16 weeks, a subgroup of animals underwent additional radiotherapy. Results: MRE was sensitive to early tumor invasion and MRE and ADC captured radiotherapy effects so far not detectable with established MRI-sequences. Impact: In a preclinical setting the ADC and especially MRE allow for a better characterization of therapeutic effects and tumor cell invasion and should thus also be evaluated in a clinical setting.
Authors
- Chenchen Pan (ORCID: https://orcid.org/0000-0001-8234-6870)
- Frank Winkler (ORCID: https://orcid.org/0000-0003-4892-6104)
- Martin Bendszus (ORCID: https://orcid.org/0000-0002-9094-6769)
- Michael O. Breckwoldt (ORCID: https://orcid.org/0000-0002-9980-2390)
- Berin Boztepe
- Ina Weidenfeld
- Amir Abdollahi (ORCID: https://orcid.org/0000-0002-8016-5897)
- Katharina Schregel (ORCID: https://orcid.org/0000-0003-4367-1667)
- Sabine Heiland (ORCID: https://orcid.org/0000-0002-2796-3451)
- Yannik Streibel
- Hannah Fels-Palesandro
- Manuel Fischer (ORCID: https://orcid.org/0000-0001-7459-1024)
- Volker Sturm (ORCID: https://orcid.org/0000-0001-8681-9372)
- Ralph Sinkus
- Sophie Heuer (ORCID: https://orcid.org/0000-0002-3373-5295)
- Daniel Dominguez-Azorin
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0053
- Primary Topic
- Elasticity and Material Modeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00