Restriction Spectrum Imaging (RSI) Models for Cervical Cancer

Motivation: Restriction spectrum imaging (RSI) has demonstrated potential to isolate cervical cancer signal from that of surrounding tissues. Women with post-treatment disease progression wait 3-6 months post treatment to get PET/CT exam to allow for edema/inflammation to subside. Cervical cancer-specific RSI model may allow us to evaluate response-to-treatment earlier. Goal(s): The goal of this work was to develop an RSI cervical cancer model from a larger cohort of patients. Approach: We used RSI-derived information from normal cervixes to convert RSI outputs to Z-score maps in cancer patients. Results: Demonstrated the utility of RSI Z-score maps in differentiating cancers from healthy tissues without exogenous contrast. Impact: Standard of care evaluation of cervical cancer response-to-treatment is PET/CT 3-6 months post-treatment to allow for edema/inflammation to subside. Cervical cancer-specific RSI model may allow us to evaluate response-to-treatment earlier and better inform patient treatment response without unnecessary delay.