IVIM Combined with DCE-MRI Characterize Architectural Distortion Detected on Mammography: A Pilot Study

Motivation: Breast adenosis (AD) detection is crucial for early breast cancer diagnosis. Traditional mammography has limitations. Goal(s): To enhance AD diagnosis using MRI and evaluate MRI's diagnostic value for AD detected in mammography. Assess the combined potential of dynamic contrast-enhanced MRI (DCE-MRI) and intravoxel incoherent motion (IVIM) sequences. Approach: Collected data from AD-diagnosed patients who underwent breast MRI. Analyzed DCE-MRI and IVIM parameters, compared benign and malignant AD, and assessed their combined diagnostic efficiency. Results: MRI exhibited high sensitivity (100%) and NPV (100%) for malignancy exclusion. DCE-MRI and IVIM combined yielded superior results with an AUC of 0.984. Impact: This study demonstrates that combining DCE-MRI and IVIM significantly enhances the diagnostic accuracy of AD changes. It offers a non-invasive approach to differentiate benign from malignant lesions, reducing unnecessary invasive procedures and improving breast cancer management.