Venous Return in Chronic Obstructive Pulmonary Disease Assessed with 4D Flow MRI
Motivation: Chronic obstructive pulmonary disease (COPD) and emphysema are associated with hemodynamic changes in the pulmonary vasculature, possibly related to increased intra-thoracic pressure during expiration, altering venous return into the thorax. Goal(s): Assess the association of respiratory dysfunction with hemodynamic parameters of venous return. Approach: Velocity, kinetic energy, and stasis in the superior vena cava and inferior vena cava were quantified with 4D Flow MRI in 72 subjects across the COPD spectrum in an ongoing study (SPIROMICS HF). Results: Our results show an association of impaired (reduced) venous return to the thorax with airway obstruction as assessed by spirometry. Impact: This study demonstrates impaired venous return in subjects with COPD, which warrant further investigations into the cardiopulmonary interactions of right heart flow in COPD and its potential value as a noninvasive marker of disease progression.
Authors
- J. Paul Finn (ORCID: https://orcid.org/0000-0002-4534-7572)
- Joyce Schroeder (ORCID: https://orcid.org/0000-0002-7451-4886)
- Sachin Jambawalikar (ORCID: https://orcid.org/0000-0003-1839-6798)
- Michael Backman
- Christopher S. Cooper (ORCID: https://orcid.org/0000-0002-4169-2088)
- Wei Shen (ORCID: https://orcid.org/0000-0003-4838-4923)
- Michael Markl (ORCID: https://orcid.org/0000-0002-7686-1128)
- Prachi Agarwal (ORCID: https://orcid.org/0000-0002-4439-6970)
- Oliver Wieben (ORCID: https://orcid.org/0000-0002-7931-1930)
- Jing Liu (ORCID: https://orcid.org/0000-0002-3311-0818)
- Dalane W. Kitzman (ORCID: https://orcid.org/0009-0000-5274-0826)
- Bharath Ambale‐Venkatesh (ORCID: https://orcid.org/0000-0002-2330-2373)
- David Dushfunian (ORCID: https://orcid.org/0000-0002-0628-1961)
- João L. M. P. de Lima (ORCID: https://orcid.org/0000-0002-0135-2249)
- Yoo Jin Lee (ORCID: https://orcid.org/0000-0003-2799-6242)
- R. Graham Barr (ORCID: https://orcid.org/0000-0002-0743-2303)
- James Carr
- David Bluemke
- Tex Houston
- Martin Prince
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0090
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00