Identification of 9.4T MRI sequences for enhanced cellular visualisation of Multiple Sclerosis lesions
Motivation: Accurately analyzing cell presence in multiple sclerosis (MS) lesions via magnetic resonance imaging (MRI) cannot be achieved without histopathological validation. Goal(s): Identification of biomarkers in MRI responsible for capturing microstructural alterations in brain tissues. Approach: Investigation of relations in the ratio between lesion and normal-appearing white matter (NAWM) in voxel values of postmortem 9.4 T MRI scans and in cell density values of histochemical images of three MS lesions. Results: We identified effective MRI sequences enhancing the contrast between the different features of the lesions and the NAWM and linked them to different cell type presence, as detected via quantitative histochemical analysis. Impact: The establishment of a robust connection between MRI data and histochemical features will improve our understanding of the MS lesions development and its impact on the brain microstructure.
Authors
- Riccardo Galbusera (ORCID: https://orcid.org/0000-0002-3092-8737)
- Valerij G. Kiselev (ORCID: https://orcid.org/0000-0002-5349-5399)
- Alessandro Cagol (ORCID: https://orcid.org/0000-0002-7703-0553)
- Christine Stadelmann (ORCID: https://orcid.org/0000-0003-1766-5458)
- Ilaria Callegari (ORCID: https://orcid.org/0000-0003-3361-3084)
- Jochen Leupold (ORCID: https://orcid.org/0000-0002-2582-9451)
- Po‐Jui Lu (ORCID: https://orcid.org/0000-0001-6031-6865)
- Dominik von Elverfeldt (ORCID: https://orcid.org/0000-0002-6219-3528)
- Matthias Weigel (ORCID: https://orcid.org/0000-0002-4910-1414)
- Bibek Dhital
- Mario Ocampo‐Pineda (ORCID: https://orcid.org/0000-0003-2239-7355)
- Erik Bahn (ORCID: https://orcid.org/0009-0002-9747-0211)
- Cristina Granziera (ORCID: https://orcid.org/0000-0002-4917-8761)
- Elena Giacomelli (ORCID: https://orcid.org/0000-0003-1985-6434)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2956
- Primary Topic
- Cell Image Analysis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00