Reproducibility of quantitative MRI measures at Ultra-Low Field
Motivation: Ultra-low field scanners can vastly improve access to neuroimaging, and implementing MRI techniques to quantify microstructure allows monitoring of both neurodegenerative diseases as well as myelination trajectories during development. Goal(s): To assess the reliability of microstructure-sensitive methods at ultra-low field before large-scale deployment. Approach: The reliability of recently developed magnetization transfer (MT) imaging and T2 mapping sequences at 64mT was assessed in 5 healthy subjects through histograms, difference maps and correlation analysis in white matter. Results: Both MT ratios and T2 values were highly reproducible in the test cohort. Impact: Techniques to measure microstructure, even semi-quantitatively, can be useful for tracking myelination/demyelination. Here we demonstrate the reproducibility of two such methods: magnetization transfer imaging and T2 mapping, in a small cohort of healthy adults at ultra-low field (64mT).
Authors
- Rui Pedro A. G. Teixeira (ORCID: https://orcid.org/0000-0001-6508-9315)
- Adam Dvorak (ORCID: https://orcid.org/0000-0001-6107-5610)
- Shannon Kolind (ORCID: https://orcid.org/0000-0003-1362-1968)
- Alex L. MacKay (ORCID: https://orcid.org/0000-0002-3282-0463)
- Neale Wiley
- Steven Williams (ORCID: https://orcid.org/0000-0003-4299-1941)
- Megan Poorman (ORCID: https://orcid.org/0000-0001-5474-8776)
- Sharada Balaji (ORCID: https://orcid.org/0000-0002-6232-8488)
- Francesco Padormo (ORCID: https://orcid.org/0000-0001-5699-2692)
- Emil Ljungberg (ORCID: https://orcid.org/0000-0003-1456-7967)
- Tobias Wood (ORCID: https://orcid.org/0000-0001-7640-5520)
- Sean Deoni (ORCID: https://orcid.org/0000-0002-0633-6328)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2832
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00