Accurate Estimation of Kidney Volume Growth Rates from abdominal MRI via Fitting to multiple Imaging Timepoints (FIT) in ADPKD

Motivation: Height-adjusted total kidney volume (htTKV) growth rate measured on MRI or CT is a critical biomarker for monitoring autosomal dominant polycystic kidney disease (ADPKD) progression. Goal(s): This study aims to develop a tool for accurate calculation of the htTKV growth rate based on all available MRI scans. Approach: Accuracy of four MRI methods for calculating htTKV growth rate were assessed as compared to ground truth calculated from 10+ years of imaging follow up. Results: Using 2-parameter least squares fitting with 3+ scans or 5+ years of follow up reduce error 2-fold compared to the current clinical standard, Mayo Imaging Classification. Impact: Accurate estimation of kidney growth rate on abdominal MRI using FIT will enable better prediction of disease progression and response to therapy in patients with ADPKD.