Evaluation of a cervical cancer-specific restriction spectrum imaging model on an independent pilot cohort using PET/MRI: pre- and post-therapy
Motivation: Restriction spectrum imaging (RSI) can potentially improve cervical cancer evaluation pre- and post-therapy, particularly in separating persistent malignancy from post-treatment edema. Goal(s): To evaluate a cervical cancer-specific RSI model for assessment on an independent pilot cohort examined with combined PET/MRI. Approach: Four patients underwent PET/MRI before (chemo)radiotherapy. Two of them also underwent PET/MRI within 4 weeks of treatment, MRI 3 months post-treatment and PET/MRI 6 months post-treatment. Two healthy volunteers underwent MRI only. Results: Preliminary results showed increased tumor conspicuity on RSI compared to conventional pre-therapy PET/MRI and promising results early post-therapy. Impact: Cervical cancer-specific restriction spectrum imaging (RSI), evaluated on an independent pilot cohort, indicates increased tumor conspicuity compared to conventional pre-therapy PET/MRI and promising results post-therapy. Future work will target early therapy response assessment in combined RSI-PET/MRI at a larger scale.
Authors
- Joshua Kuperman (ORCID: https://orcid.org/0000-0002-7890-4785)
- Rebecca Rakow‐Penner (ORCID: https://orcid.org/0000-0002-2566-1978)
- Jennifer Peterson (ORCID: https://orcid.org/0000-0001-7458-1504)
- Katarzyna Kozar (ORCID: https://orcid.org/0000-0002-2397-2975)
- Elin Lundström (ORCID: https://orcid.org/0000-0003-2955-4958)
- Arnaud Guidon (ORCID: https://orcid.org/0000-0001-6777-1633)
- Björg Jónsdóttir (ORCID: https://orcid.org/0000-0001-8962-4351)
- Stéphane Loubrie (ORCID: https://orcid.org/0009-0009-0526-2281)
- Ana Rodríguez-Soto (ORCID: https://orcid.org/0000-0002-1553-5177)
- Stephan Jordan
- Alexandra Schlein (ORCID: https://orcid.org/0000-0002-3821-5723)
- Tyler M. Seibert (ORCID: https://orcid.org/0000-0002-4089-7399)
- Elisabeth Hedlund
- Anthoula Koliadi
- Anders M. Dale (ORCID: https://orcid.org/0000-0002-6126-2966)
- Christopher C. Conlin (ORCID: https://orcid.org/0000-0003-4509-8702)
- Sheida Ebrahimi
- Per Liss (ORCID: https://orcid.org/0000-0003-4379-0906)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0179
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00