Investigating hippocampal-cortical and cortical-cortical connectivity changes during pattern separation: a 7T fMRI study
Motivation: Studies have extensively demonstrated roles of hippocampus and its subdivisions during pattern separation, but cortical involvement has not yet been elucidated. Goal(s): Our goal is to evaluate whole-brain functional connectivity changes during pattern separation. Approach: We compared cortical-hippocampus and cortical-cortical FNCs during a total of 258 correct and incorrect lure discrimination trials, using high-resolution and high-quality 7T fMRI data. Results: Cortical-CA3DG FNCs and cortical-CA1 FNCs were significantly involved during pattern separation and completion, respectively. Around 83.35% cortical-cortical connections were with higher FNCs during lure discriminations, indicating their potential involvement during pattern separation. Impact: Besides hippocampus and its subdivisions, cortical regions and its connections to hippocampus might be extensively involved in pattern separation process.
Authors
- Dietmar Cordes (ORCID: https://orcid.org/0000-0001-6574-5546)
- Xiaowei Zhuang (ORCID: https://orcid.org/0000-0002-0581-6530)
- Katherine Koenig (ORCID: https://orcid.org/0000-0002-1504-7130)
- Mark E. Lowe (ORCID: https://orcid.org/0000-0002-5116-3841)
- James B. Leverenz (ORCID: https://orcid.org/0000-0002-0896-0749)
- Tim Curran (ORCID: https://orcid.org/0000-0003-4689-8306)
- Zhengshi Yang (ORCID: https://orcid.org/0000-0002-9796-9680)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0332
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00