CHEAP and SLOW: a comprehensive acquisition protocol for downfield, upfield, and spectral editing 1H-MRSI at 7T

Motivation: Integration of downfield, upfield, and spectral editing MRSI in clinical studiesGoal(s): Generate high resolution downfield (0.37 ml) and upfield (0.2 ml) in vivo MRSI at 7TApproach: CHEAP-ESPI and SLOW-EPSI were used for downfield and upfield (spectral editing) MRSI, respectively, in two healthy volunteers and one glioma patient. Results: A 4-minute acquisition with CHEAP-EPSI suffices for downfield MRSI (ATP/GSH+ and NAA+), while a 9-minute acquisition with SLOW-EPSI is adequate for upfield (NAA) and spectral editing (2HG, GABA, and Glx) MRSI. Impact: The combination of CHEAP-EPSI and SLOW-EPSI enables the measurement of downfield, upfield, and edited 3D MRSI within approximately 13 minutes, making it readily integrable into clinical routine examinations or scientific studies.