Clinical evaluation of patients with recurrent glioblastoma using hyperpolarized carbon-13 metabolic imaging
Motivation: Despite aggressive treatments, patients with GBM have a median overall survival of 14-16 months and a need for noninvasive evaluation of therapeutics is apparent. Goal(s): To assess whether treatment-induced metabolic changes can be observed in patients using parameters derived from hyperpolarized 13C metabolic imaging data. Approach: 19 patients with recurrent GBM were followed for at least 6 months following treatment initiation and evaluated at various timepoints using HP-13C imaging. Results: A difference in trends following treatment was observed in pyruvate-to-lactate conversion for patients who received anti-angiogenic treatments as compared to those who received a protein kinase inhibitor. Impact: Given the challenges associated with evaluating progression and response to therapy in patients with glioblastoma using conventional MRI, this study provided evidence that hyperpolarized carbon-13 techniques can detect serial changes in dynamic metabolism which might help predict disease status.
Authors
- Janine Lupo (ORCID: https://orcid.org/0000-0002-0051-6387)
- Duan Xu (ORCID: https://orcid.org/0000-0003-0550-4235)
- Daniel B. Vigneron (ORCID: https://orcid.org/0000-0001-5795-8699)
- Hsin‐Yu Chen (ORCID: https://orcid.org/0000-0002-2765-1685)
- Peder E. Z. Larson (ORCID: https://orcid.org/0000-0003-4183-3634)
- Yaewon Kim (ORCID: https://orcid.org/0000-0003-1016-1572)
- Jeremy W. Gordon (ORCID: https://orcid.org/0000-0003-2760-4886)
- Javier Villanueva‐Meyer (ORCID: https://orcid.org/0000-0002-1212-4233)
- Jennifer Clarke (ORCID: https://orcid.org/0000-0002-8054-7342)
- Adam Autry (ORCID: https://orcid.org/0000-0002-7062-4965)
- Sana Vaziri
- Marisa Lafontaine (ORCID: https://orcid.org/0000-0002-2352-3299)
- Nancy Ann Oberheim Bush (ORCID: https://orcid.org/0000-0001-8302-5008)
- Yan Li (ORCID: https://orcid.org/0000-0002-3906-9481)
- Susan M. Chang
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0371
- Citations
- 1
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.24