T1234: A distortion-matched structural scan solution to misregistration of high resolution fMRI data

Motivation: High-resolution fMRI at 7T is limited by misregistration of functional data with structural scans. Goal(s): We aim to provide a fast acquisition method that provides distortion matched, artifact mitigated structural reference data. Approach: T1234: T1-weighted 2-inversion 3D-EPI with 4 directions for high-resolution fMRI. A forward Bloch model is implemented for T1 quantification and protocol optimization. Results: Our protocol is fast (3:40 min) and provides whole-brain segmentations in EPI-space. It is robust across sessions, participants, and scanners. Impact: This structural mapping approach allows precise registration with fMRI data. T1234 is implemented, validated, and tested to serve users of our sequence (locally and 43 centers worldwide).