Imaging Tumor Metabolism in Patients with Head & Neck Squamous Cell Carcinoma
Motivation: Changes in metabolic imaging biomarkers offer tremendous potential for assessing response and optimizing treatment for patients with head and neck squamous cell carcinoma (HNSCC). Goal(s): To assess the translational viability of metabolic MRI with hyperpolarized (HP) pyruvate in patients with HNSCC. Approach: Patients with HNSCC are recruited into a prospective imaging study and scanned with HP [1-13C]-pyruvate in a test-retest paradigm before start of therapy. Results: Preliminary data indicates that reproducibility of semi-quantitative measures of tumor metabolism are high, with correlation between test-retest measurements >80% in all voxels that exceed a minimum SNR threshold and correlation >96% in regions identified as tumor. Impact: These results demonstrate that metabolic MRI with hyperpolarized [1-13C]-pyruvate generates sufficient SNR and spatiotemporal resolution to permit reproducible measurement of tumor metabolism in patients with HNSCC.
Authors
- William H. Morrison (ORCID: https://orcid.org/0000-0002-9546-0805)
- Brandy Reed
- Vlad C. Sandulache (ORCID: https://orcid.org/0000-0002-9205-385X)
- Yunyun Chen
- Michelle Underwood
- Christopher M. Walker (ORCID: https://orcid.org/0000-0002-6381-8737)
- Stacy Hash
- Clifton D. Fuller (ORCID: https://orcid.org/0000-0002-5264-3994)
- Andrew G. Day (ORCID: https://orcid.org/0000-0002-1095-5703)
- Joshua Jones (ORCID: https://orcid.org/0000-0001-9047-9147)
- James A. Bankson (ORCID: https://orcid.org/0000-0002-8574-154X)
- Ehab Y. Hanna (ORCID: https://orcid.org/0000-0003-3241-2440)
- Stephen J. Schuster (ORCID: https://orcid.org/0000-0002-3376-8978)
- Stephen Y. Lai (ORCID: https://orcid.org/0000-0001-8301-7286)
- Keith A. Michel (ORCID: https://orcid.org/0000-0002-4330-6881)
- Dawid Schellingerhout (ORCID: https://orcid.org/0000-0003-3659-435X)
- José M. González (ORCID: https://orcid.org/0000-0002-5488-7845)
- Luana Sousa
- Moin Chariwala
- Stephanie Carlon
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3075
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00