Monitoring diabetic kidney disease progression with DTI and tractography
Motivation: Previous studies have shown that DTI and tractography may act as early indicator of DKD. Goal(s): The aim of this study was to identify DTI biomarkers that may be sensitive to changes over a relatively short 2-year time frame in early-stage DKD. Approach: Thirteen type-2 diabetic patients were scanned two times during a two-year period on a 3T MRI scanner using a free-breathing diffusion protocol. 180 biomarkers from DTI and tractography were calculated with DIPY. Results: 46 biomarkers showed a significant change over the 2 years, with mean changes that reach over ½ of a standard-deviation and cohen-d effect-sizes up to 0.6Impact: DTI biomarkers show strong changes in early-stage diabetic kidney disease over 2-years, a time frame where clinical biomarkers are typically stable. This finding may have significant implications for clinical practice if confirmed in the larger population.
Authors
- Mark Gilchrist (ORCID: https://orcid.org/0000-0002-0284-6048)
- Michael Mansfield (ORCID: https://orcid.org/0000-0002-1044-3935)
- David Shelley
- Maria F. Gomez (ORCID: https://orcid.org/0000-0001-6210-3142)
- Kywe Kywe Soe (ORCID: https://orcid.org/0000-0002-5372-0525)
- João Periquito (ORCID: https://orcid.org/0000-0003-3702-9264)
- Angela C. Shore (ORCID: https://orcid.org/0000-0003-3039-308X)
- Kanishka Sharma (ORCID: https://orcid.org/0000-0002-0693-1071)
- Kim M. Gooding (ORCID: https://orcid.org/0000-0002-1825-9825)
- Steven Sourbron (ORCID: https://orcid.org/0000-0002-3374-3973)
- Jonathan Fulford (ORCID: https://orcid.org/0000-0002-5945-1688)
- Bashair Alhummiany (ORCID: https://orcid.org/0000-0002-1891-1721)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0780
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00