Assessing Regional Lung Function with Chemical Shift Imaging - Chemical Shift Saturation Recovery (CSI-CSSR) Using Hyperpolarized Xenon-129
Motivation: Chemical shift saturation recovery (CSSR) MR spectroscopy using hyperpolarized xenon-129 (HXe) is sensitive to abnormal lung function but lacks regionality. Goal(s): Add regional information to CSSR MR spectroscopy with variable echo time (TE) chemical shift imaging (CSI). Approach: Comparison of CSI-CSSR to global CSSR measurements in the lungs of a healthy and an irradiated rat. Results: CSI-CSSR yields results comparable to whole-lung CSSR spectroscopy but with added regionality. Impact: CSI-CSSR allows the regional quantification of apparent alveolar septal wall thickness, T2*, and resonance frequency shifts. This approach greatly enhances the sensitivity for the detection of abnormal xenon gas-exchange processes in heterogeneous lung disease.
Authors
- L. Loza (ORCID: https://orcid.org/0000-0001-8812-7118)
- Jiawei Chen (ORCID: https://orcid.org/0000-0002-2970-1068)
- Hooman Hamedani (ORCID: https://orcid.org/0000-0002-9385-3082)
- Stephen Kadlecek (ORCID: https://orcid.org/0000-0002-5131-7994)
- Kai Ruppert (ORCID: https://orcid.org/0000-0002-7292-6019)
- F. Amzajerdian (ORCID: https://orcid.org/0000-0002-1326-9581)
- Ian C. Duncan
- Mostafa Ismail (ORCID: https://orcid.org/0000-0002-5147-8798)
- Rahim Rizi (ORCID: https://orcid.org/0000-0002-3040-7472)
- Harrilla Profka
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3202
- Primary Topic
- Atomic and Subatomic Physics Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00