Echo time optimization of 2HG-edited MRS and T2 determination of tumor metabolites at 3T

Motivation: 2HG is an important oncometabolite which is commonly detected using J-difference editing. Goal(s): Here, we determined the optimal echo time for J-difference editing of 2HG at 3T. Approach: This was done by evaluating the echo time dependence of the 2HG-edited signal using simulations and in vivo experiments. We also quantified the T2 relaxation of 2HG as well as the co-edited glutamate and glutamine signalsResults: A TE of 90 ms was found to produce the highest signal, however, a TE of 70 ms was found to provide the best separation between 2HG and Glx in poor shimming conditions. Impact: This optimized J-difference edited sequence could improve MRS measurements of 2HG. This would take MRS one step closer towards clinical applicability which could aid in the diagnosis and treatment monitoring of glioma patients.