White matter neurite alterations in dementia with Lewy body bodies: influence of amyloid-β and tau
Motivation: The influence of Alzheimer’s disease (AD) copathologies on white matter neurite changes in dementia with Lewy bodies (DLB) remains unclear. Goal(s): To delineate the severity of neurite abnormalities and their associations with amyloid and tau PET imaging in DLB. Approach: We compared Neurite Orientation Dispersion and Density Imaging metrics in the DLB spectrum (DLBs, n=45) against controls (n=45), and evaluated their correlations with amyloid-β ([11C]-PiB) and tau ([18F]-Flortaucipir) PET. Results: The DLBs exhibited widespread white matter injury relative to controls. Elevated tau deposition, but not amyloid-β burden, was significantly associated with neurite abnormalities, predominantly involving the temporal and limbic white matter tracts. Impact: These findings demonstrate the impact of AD copathologies on widespread neurite abnormalities in people with DLB, underscoring the importance of further elucidating the mechanisms underlying amyloid-β and tau deposition, and evaluating anti-AD disease-modifying interventions for DLB.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Jonathan Graff‐Radford (ORCID: https://orcid.org/0000-0003-2770-0691)
- Robert I. Reid (ORCID: https://orcid.org/0000-0003-2391-8650)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- David Jones
- John T. O’Brien (ORCID: https://orcid.org/0000-0002-0837-5080)
- Scott A. Przybelski (ORCID: https://orcid.org/0009-0009-3437-3773)
- Vijay K. Ramanan (ORCID: https://orcid.org/0000-0001-6591-8734)
- Bradley Boeve
- Tanis J. Ferman (ORCID: https://orcid.org/0000-0001-8377-6194)
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Julie A. Fields (ORCID: https://orcid.org/0000-0002-1282-9866)
- Hugo Botha (ORCID: https://orcid.org/0000-0003-4390-685X)
- Matthew L. Senjem (ORCID: https://orcid.org/0000-0001-9308-9275)
- Sheelakumari Raghavan (ORCID: https://orcid.org/0000-0001-8652-7011)
- Elijah Mak (ORCID: https://orcid.org/0000-0002-6437-8024)
- Toji Miyagawa (ORCID: https://orcid.org/0000-0002-9387-0253)
- Timothy G. Lesnick (ORCID: https://orcid.org/0000-0002-4126-5924)
- Rodolfo Savica (ORCID: https://orcid.org/0000-0002-2543-0627)
- Christopher G. Schwarz (ORCID: https://orcid.org/0000-0002-1466-8357)
- Manoj Jain (ORCID: https://orcid.org/0000-0003-3096-5957)
- Ronald Petersen
- Leah K. Forsberg (ORCID: https://orcid.org/0000-0003-4086-9598)
- Kejal Kantarci (ORCID: https://orcid.org/0000-0002-8001-2081)
- Hoon‐Ki Min (ORCID: https://orcid.org/0000-0002-1084-2469)
- Erik K. St. Louis (ORCID: https://orcid.org/0000-0002-2833-8826)
- David S. Knopman
- Neill R. Graff‐Radford
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0108
- Citations
- 1
- Primary Topic
- Brain Tumor Detection and Classification
- Type
- article
- Field-Weighted Citation Impact
- 0.25