APTw Combined with Multiple Models DWI of Endometrial Cancer: Correlations between Multimodal Parameters and HIF-1α Expression

Motivation: Hypoxia inducible factor (HIF-1α) is a major transcriptional factor regulating gene expression under hypoxic conditions and could serve as an important biomarker for tumor aggressiveness or radiation resistance. Goal(s): This study aimed to investigate whether the multimodal functional MRI technique can be used for quantitatively measuring HIF-1α expression. Approach: APT, ADC, D, D*, f, MK, and MD values were calculated and compared between HIF-1α high expression and HIF-1α low expression groups. Results: APT, ADC, D, D*, MK and MD values were significantly higher in high HIF-1α expression than in low HIF-1α expression groups, whereas f value was significantly lower in high HIF-1α expression . Impact: The quantitative parameters of APTw combined with multi-model diffusion-weighted sequences allowed quantitative assessment of EC HIF-1α expression, and the combined quantitative parameters further enhanced the assessment efficacy.