Longitudinal Trends and Effects in Placenta Multiparametric MRI (mpMRI) in Early Gestation

Motivation: This study is motivated by the clinical need to understand and monitor early gestational placenta development. Goal(s): The goal is to show that multi-parametric placenta imaging during early gestation is a clinical tool to flag possible pregnancies in danger of multiple adverse effects. Approach: This study includes data from a previous perspective study where MRI was taken at two separate timepoints during early gestation. Information on volume, perfusion, and oxygenation were evaluated for longitudinal trends as well as changes driven by obesity and fetal sex outcomes. Results: We show statistically significant differences of longitudinal trends in most of the parameters between study cohorts. Impact: The results in this study could allow for clinicians to gain insight on pregnancy development within the early second trimester currently unavailable with the current imaging with Doppler ultrasound. This will allow for overall life improvement for mother and fetus.