7.0T CMR-TT evaluate quantitatively the effect of nicotinamide mononucleotide on experimental autoimmune myocarditis via ferroptosis

Motivation: To evaluate the diagnosis and follow-up value of CMR-TT in myocarditis. To explore more treatment strategies for myocarditis and the potential mechanism. Goal(s): Using 7.0T CMR-TT to evaluate the effect of nicotinamide mononucleotide (NMN) for experimental autoimmune myocarditis and exploring the potential mechanism. Approach: Lewis rats were induced to be autoimmune myocarditis by porcine cardiac myosin and treated by NMN. The strains of rats were detected by 7.0T CMR-TT. Histopathology, biochemistry and ELISA were used for myocardial damage and ferroptosis. Results: Strains reduction in EAM was alleviated by NMN. The changes of cardiac and ferroptosis biomarkers were relieved by NMN. Impact: CMR-TT can provide the imaging evidence for the diagnosis and follow-up of myocarditis. The study will provide more options and targets for clinicians to treat myocarditis.