Comparison of the spatial distribution of BOLD Regional Homogeneity (ReHo) and Cerebral Blood Flow at rest

Motivation: Regional Homogeneity (ReHO) of BOLD signal is a potential marker of brain activity at rest. CBF is coupled to metabolism in the human brain and it can be used to investigate the physiological significance of ReHo. Goal(s): We aimed to assess the spatial correlation between ReHo and ASL-derived CBF and its temporal stability. Approach: Twenty subjects underwent 28 minutes of simultaneously acquired BOLD-ASL resting-state fMRI. CBF and ReHo spatial associations at different times were estimated and compared. Results: We found a modest but stable and significant spatial correlation between CBF and ReHo. Impact: This study could be significant for diagnosis and treatment of neurological disorders. If ReHo is demonstrated to be a reliable marker of local brain metabolism, it could be used to develop new fMRI methods for detecting and monitoring brain disorders.

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Publication Details

Journal
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Published
2024-11-26
DOI
https://doi.org/10.58530/2024/3152
Primary Topic
Cerebrovascular and Carotid Artery Diseases
Type
article
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article

Comparison of the spatial distribution of BOLD Regional Homogeneity (ReHo) and Cerebral Blood Flow at rest

Francesca Graziano, Eleonora Patitucci, Stefano Censi, Antonio Maria Chiarelli et al.
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Cerebrovascular and Carotid Artery Diseases
article

Comparison of the spatial distribution of BOLD Regional Homogeneity (ReHo) and Cerebral Blood Flow at rest

Francesca Graziano, Eleonora Patitucci, Stefano Censi, Antonio Maria Chiarelli, Alessandra Caporale, Valentina Tomassini, Michael Germuska, Emma Biondetti, Richard G. Wise, Davide Di Censo
article en

Abstract

Motivation: Regional Homogeneity (ReHO) of BOLD signal is a potential marker of brain activity at rest. CBF is coupled to metabolism in the human brain and it can be used to investigate the physiological significance of ReHo. Goal(s): We aimed to assess the spatial correlation between ReHo and ASL-derived CBF and its temporal stability. Approach: Twenty subjects underwent 28 minutes of simultaneously acquired BOLD-ASL resting-state fMRI. CBF and ReHo spatial associations at different times were estimated and compared. Results: We found a modest but stable and significant spatial correlation between CBF and ReHo. Impact: This study could be significant for diagnosis and treatment of neurological disorders. If ReHo is demonstrated to be a reliable marker of local brain metabolism, it could be used to develop new fMRI methods for detecting and monitoring brain disorders.

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
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Cerebrovascular and Carotid Artery Diseases
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