Improved MR Multitasking-based Dynamic Imaging for Cerebrovascular Evaluation (MT-DICE): Towards Multiparametric Brain Tumor Evaluation

Motivation: The lack of pathophysiologically relevant quantitative information hinders the precision management of brain tumors. Specifically, the characterization of intra-tumor heterogeneity influencing treatment decision-making, remains a critical challenge. Goal(s): This work aims to optimize a recently developed technique MT-DICE, to provide multiparametric mapping information for more comprehensive brain tumor evaluation. Approach: The MT-DICE technique was further refined by including 3D flow compensation, dictionary-based mapping, and water exchange quantification. Assessments for the repeatability of MT-DICE parameters and their agreement with routine measurements were performed. Results: Excellent reproducibility and agreement were achieved. Spatially co-registered multiparametric maps from MT-DICE facilitated comprehensive brain tumor characterization. Impact: Individuals with brain tumors may benefit from more comprehensive brain tumor evaluation using multiparametric maps derived from our improved MT-DICE technique.