Correlation Between Cortical Thickness and Motor Functions in Individuals with Cerebral Small Vessel Disease Burdens

Motivation: Delve into the cortical territories most vulnerable to cerebral small vessel disease (CSVD)Goal(s): Determine the pivotal cortical zones that play a crucial role in mediating motor dysfunction in patients affected by CSVD, and scrutinize the risk factors that could potentially influence these pertinent cerebral areas. Approach: Cortical thickness measurements were acquired utilizing an integrated approach of magnetic resonance imaging (MRI) and FreeSurfer technology. Results: The right insular cortex holds a crucial position in the cascade of motor impairments observed in individuals diagnosed with CSVD. Body Mass Index (BMI) emerges as a potentially vital risk factor. Impact: Focusing on the cortical thickness of the right insular cortex in individuals with CSVD and the risk factors that influence it (such as BMI) may lead to a better understanding and early intervention for motor impairment in individuals with CSVD.